Alexander S Kauffman Selected Research

Kisspeptin-1 Receptors

1/2022	Developmental sex differences in the peri-pubertal pattern of hypothalamic reproductive gene expression, including Kiss1 and Tac2, may contribute to sex differences in puberty onset.
1/2020	Conditional knockout of kisspeptin signaling in brown adipose tissue increases metabolic rate and body temperature and lowers body weight.
12/2019	Cre/lox generation of a novel whole-body Kiss1r KO mouse line recapitulates a hypogonadal, obese, and metabolically-impaired phenotype.
11/2016	Metabolism and Energy Expenditure, But Not Feeding or Glucose Tolerance, Are Impaired in Young Kiss1r KO Female Mice.
10/2016	Unaltered Hypothalamic Metabolic Gene Expression in Kiss1r Knockout Mice Despite Obesity and Reduced Energy Expenditure.
7/2014	Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity.

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Alexander S Kauffman Research Topics

Disease

6	Body Weight (Weight, Body) 01/2022 - 08/2005
6	Obesity 01/2020 - 01/2014
4	Glucose Intolerance 12/2019 - 07/2014
3	AIDS-Related Complex (ARC) 01/2022 - 04/2007
3	Hypogonadism (Hypergonadotropic Hypogonadism) 12/2019 - 08/2007
2	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 01/2020 - 09/2015
2	Anovulation 01/2020 - 08/2019
2	Precocious Puberty 01/2013 - 03/2009
1	Ovarian Pregnancy 04/2018
1	Infertility (Sterility) 10/2014
1	Idiopathic Hypogonadotropic Hypogonadism 10/2014
1	Feminization 09/2013
1	Virilism (Virilization) 09/2012
1	Prostatic Neoplasms (Prostate Cancer) 03/2009
1	Endometriosis 03/2009
1	Lordosis 08/2004
1	Starvation 07/2004

Drug/Important Bio-Agent (IBA)

10	KisspeptinsIBA 01/2022 - 03/2009
6	Kisspeptin-1 ReceptorsIBA 01/2022 - 07/2014
5	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2022 - 08/2005
4	LeptinIBA 10/2016 - 07/2004
2	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 07/2014
2	Estradiol (Delestrogen)FDA LinkGeneric 01/2020 - 09/2013
2	Luteinizing Hormone (Lutropin)FDA LinkGeneric 01/2020 - 08/2005
2	Letrozole (Femara)FDA LinkGeneric 01/2020 - 09/2015
2	AndrogensIBA 08/2019 - 09/2012
2	Messenger RNA (mRNA)IBA 09/2015 - 04/2007
1	Testosterone (Sustanon)FDA Link 01/2020
1	Peptides (Polypeptides)IBA 04/2018
1	Estrogens (Estrogen)FDA Link 07/2014
1	SteroidsIBA 07/2014
1	Thyroid HormonesIBA 07/2014
1	Leptin ReceptorsIBA 01/2014
1	Dihydrotestosterone (Androstanolone)IBA 09/2012
1	Neurokinin BIBA 11/2009
1	Gonadal HormonesIBA 11/2009
1	GonadotropinsIBA 11/2009
1	Hormones (Hormone)IBA 03/2009
1	estradiol 3-benzoate (estradiol benzoate)IBA 08/2005
1	Galanin-Like PeptideIBA 08/2005
1	Progesterone FDA LinkGeneric 08/2005
1	His(5)-Trp(7)-Tyr(8)- LHRHIBA 08/2004

Therapy/Procedure

1	Ovariectomy (Oophorectomy) 11/2009
1	Castration 11/2009